Polyurea Bearing L-Lysinyl Residue as a Chiral Building Block and Its Application to Optical Resolution

  •  Makoto Hatanaka    
  •  Yuki Nishioka    
  •  Masakazu Yoshikawa    


Chial polyureas were prepared from L-Lys-OEt and 2,4-TDI. The optimum polyaddition conditions were determined as follows: [L-Lys-OEt] = 2.08 x 10-1 mol dm-3 and [2,4-TDI] = 2.50 x 10-1 mol dm-3 ([L-Lys-OEt]/[2,4-TDI] = 0.83). The polyuera thus obtained gave a durable self-standing membrane and it was directly converted into molecular recognition membranes by applying an alternative molecular imprinting. The D-isomer molecularly imprinted membrane adsorbed the D-isomer in preference to the L-isomer and vice versa. In the present study, two types of print molecule, such as Z-D-Glu and Z-L-Glu, worked as print molecules though the polyurea consisted of L-lysinyl residue. Those two types of molecularly imprinted membrane showed chiral separation ability. The membrane, which was molecularly imprinted by the D-isomer and preferentially incorporated the D-isomer into the membrane, selectively transported the D-isomer and vice versa.

This work is licensed under a Creative Commons Attribution 4.0 License.
  • ISSN(Print): 1927-0585
  • ISSN(Online): 1927-0593
  • Started: 2012
  • Frequency: semiannual

Journal Metrics

Impact Factor 2022 (by WJCI):  0.583

Google-based Impact Factor (2021): 0.52
h-index (December 2021): 22
i10-index (December 2021): 74
h5-index (December 2021): N/A
h5-median (December 2021): N/A

Learn more