The Action of Puricase in Depleting Stores of Serum Urate Crystals

  •  B. E. A. Eno    
  •  E. O. Effanga    
  •  I. O. Isaac    
  •  Z. Lipscey    


From the study of purine synthesis, urate crystal deposition in joints and puricase interaction with plasma protein, a system of first order differential equations is obtained. The existence and uniqueness of the solutions of the system of equations is established. Some controllability and stabilizability results are obtained via the Pontryagins Maximum Principles.

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