Synthesis of Acids and Amino Acids by Selective Oxidation of Primary Hydroxyl Groups to Carboxylic acids in Sugars
- Natarajan Raju
- Rolf E. Swenson
Abstract
Preferential oxidation of primary hydroxyls in unprotected sugars and sugar amino acids is reported using inexpensive and readily available reagents. This method offers a specific oxidation protocol for a variety of carbohydrates. The stereochemical integrity of the starting materials was preserved and a simple workup yielded the products in good yields with high purity. The procedure is compatible with base sensitive groups like Fmoc. Both mono and disaccharides undergo oxidation regioselectively.
- Full Text:
PDF
- DOI:10.5539/ijc.v13n2p17
Index
Contact
- Albert JohnEditorial Assistant
- ijc@ccsenet.org