Abstract

Introduction: Diabetes mellitus is one of the most common metabolic disorders that cause micro- and macro-vascular complications. Because of cardiovascular disease is common in T2DM, lipid abnormalities should be evaluated in diabetes. As vitamin C, E are known for their helpful effects on plasma lipids and glycated hemoglobin (HbA1c), we evaluated the effect of these vitamins on blood glucose, plasma lipids in individuals with type 2 diabetes mellitus.

Methods: The study was carried out in 170 T2DM on consumption of vitamin C, E, combination of C & E and placebo. The subjects comprised of two main groups, supplementation and placebo group which supplementation group consists of 3 sub-groups. Each sub- group received three capsules per day for a period of three months. HbA1c, glucose and lipid profile were determined in baseline and after three months with receiving supplement.

Results: A significant decrease in FBS, TG, LDL, cholesterol and HbA1c was seen in the supplemented groups. Conclusion: This study demonstrated that patients with T2DM after three months consumption of vitamins C, E and C&E showed significantly lowered hypertension and improved insulin action and decrease lipid profile.

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