Direct Passerini Reaction of Aldehydes, Isocyanides, and Aliphatic Alcohols Catalyzed by Bismuth (III) Triflate


  •  Xiao-hua CAI    
  •  Hui GUO    
  •  Bing XIE    

Abstract

Bismuth (III) triflate was found to be effective Lewis acid catalyst for direct alkylative Passerini reaction of
aldehydes, isocyanides, and aliphatic alcohols. In the present reaction, α-unsaturated and aromatic aldehydes used as
substrates produced the corresponding α-alkoxy amide products in good yield.



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