Synthesis and Antimicrobial Study of New 8-bromo-1,3-diaryl-2,3-dihydro-1H-naphtho[1,2e][1,3]oxazines
- Anil Mayekar
- Hemmige Yathirajan
- Badiadka Narayana
- Balladka Sarojini
- Nalilu Suchetha Kumari
- William Harrison
Abstract
A series of new 8-bromo-1,3-diaryl-2,3-dihydro-1H-naphth[1,2e][1,3]oxazines 2a-n are synthesized. 6-Bromonaphthol undergoes ring closure reaction with substituted aryl and heteroarylaldehydes to give naphthoxazine derivatives. Some of these are hydrolyzed to obtain aminobenzylnaphthols 3c,l which are further condensed with different aryl/heteroaldehydes to yield 4a-e. The structures of newly synthesized compounds are confirmed through elemental analysis, spectral studies and single crystal X-ray study. Compounds are screened for their antibacterial and antifungal activity. Some of them exhibited promising activity.
- Full Text:
PDF
- DOI:10.5539/ijc.v3n1p74
Journal Metrics
h-index (December 2022): 32
i10-index (December 2022): 145
h5-index (December 2022): N/A
h5-median(December 2022): N/A
( The data was calculated based on Google Scholar Citations. Click Here to Learn More. )
Index
- Academic Journals Database
- Bibliography and Index of Geology
- CAB Abstracts
- CAS (American Chemical Society)
- COPAC
- Elektronische Zeitschriftenbibliothek (EZB)
- EuroPub Database
- Excellence in Research for Australia (ERA)
- Genamics JournalSeek
- Google Scholar
- Infotrieve
- Mendeley
- MIAR
- RePEc
- ResearchGate
- ROAD
- SHERPA/RoMEO
Contact
- Albert JohnEditorial Assistant
- ijc@ccsenet.org