Cleaner and Efficient Green Chemistry Synthesis of N,N´-Dibenzyl or N,N´-(2-Hydroxybenzyl)-Ethane-1,2-Diamine,-Propane-1,3-Diamine and -1,3-Diamino-2-Propanol

  •  Augusto Rivera    
  •  Ingrid Miranda-Carvajal    
  •  Jaime Ríos-Motta    


An efficient and highly eco-friendly protocol for the preparation of N,N´-dibenzyl or N,N´-(2-hydroxybenzyl)diamines via the reduction of the corresponding di-Schiff bases that produces a good yield using water as a solvent without the need for catalysis or the azeotropic removal of water has been developed. These symmetric diimines have been reduced to their corresponding diamines with sodium borohydride using a catalyst- and solvent-free protocol with excellent yield. Mild conditions, high yields, and a simple work-up procedure are the primary benefits of this protocol.

This work is licensed under a Creative Commons Attribution 4.0 License.
  • ISSN(Print): 1916-9698
  • ISSN(Online): 1916-9701
  • Started: 2009
  • Frequency: semiannual

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