Synthesis of Some of Fluorinated Benzimidazole Nucleosides

  •  Laila Break    


Fluorinated nucleosides very important in increased biological and chemical stability of organ fluorine compounds. Synthesis of two 5-(Trifluoromethyl)-1H-benzimidazole derivatives (3) and (4).

Ribosylation of each compound (3) and (4) with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (6) afforded mixture b- and a- anomeric of the benzoylated nucleoside derivatives (8), (9) and b- anomeric (12), respectively. Debenzoylation of the protected nucleosides by reaction with sodium metal in dry methanol yielded the corresponding free N-nucleosides (10), (11) and (13) respectively. The new synthesized compounds were characterized using the well-known spectroscopic tools (IR, 1HNMR, 13CNMR and mass spectroscopy).

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  • ISSN(Print): 1916-9698
  • ISSN(Online): 1916-9701
  • Started: 2009
  • Frequency: semiannual

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