Synthesis of novel multifluorinated pyrazolone-5-one derivatives via conventional and non-conventional methods

  •  Amol Gadakh    
  •  Chetan Pandit    
  •  Sahebrao S. Rindhe    
  •  Bhausaheb Karale    


An efficient synthesis of 3-trifluoromethyl-1-(3,4-difluorophenyl)-1H-pyrazol-5(4H)-one (3) and their
Knoevenagel condensation reaction with 1,4-diphenyl -1H-pyrazole-3-carbaldehydes 4,
4-oxo-4H-chromene-3-carbaldehydes 6 and 2-chloroquinoline-3-carbaldehydes 8 have been described by using
conventional and non-conventional techniques. Comparison of conventional and non-conventional techniques
like Microwave , Ultrasonic assisted reactions showed that, the later procedure require shorter reaction time,
good yield and was applicable for larger set of substrates emphasizing the importance of eco-friendly conditions.

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  • ISSN(Print): 1916-9698
  • ISSN(Online): 1916-9701
  • Started: 2009
  • Frequency: semiannual

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