Synthesis of Novel a-Amino Acids Bearing 1,2,4-triazinone and Steroidal Moieties as Enzymetic Affect (Cellobiase Activity) Part I


  •  Dina Abed Bakhotmah    

Abstract

An imperative class of ?-amino acids bearing 1,2,4-triazinone and N,C-disubstituted glycine (5a,b) and/or the related systems (6 and 7) have been synthesized by the condensation of 6-(2'-aminophenyl-4-phenyl-3-thion -1,2,4-triazin-5-one (1) with the appropriate steroids, Epiandrosteron (2a) and Dehydrosterone (2b), followed by the addition of hydrocyanic acid. Nucleophilic substitution of mercapto group of (5) by 4-fluoroaniline and sulfanilamide give the corresponding systems 6 and 7. Compounds 6,7, 5, and 4 showed a high enzymatic effect as cellobiase agents against some tested fungi .



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  • ISSN(Print): 1916-9698
  • ISSN(Online): 1916-9701
  • Started: 2009
  • Frequency: semiannual

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