Abstract

It is well known that Alzheimer’s and Parkinson’ s diseases are closely related with the aggregated forms of amyloid-b peptide and alpha-synuclein (a-syn) protein, respectively, and the recent work shows that neurotoxicity due to oligomeric a-syn requires the presence of copper but not iron ion. In this article, we have proposed the new insight into the toxicity due to the oligomeric amyloid-b peptide and a-syn protein induced by the copper(II) ion, based on the Nishida Reaction which is specific for the binuclear copper(II) compounds where two copper(II) ions are in close vicinity, and that copper(II)-peroxide adduct exhibits strong electrophilicity towards several organic compounds similar to the singlet oxygen (¹D_g).

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