Synthesis of Derivatives of 6H-1,2-Oxazine by Cyclization of Ketoximes With Derivatives of Terminal Acetylene Compounds

  •  Raad Yahya    
  •  Narayana Kudva N.    
  •  K. M. L. Rai    


A new series of 6H-1,2-oxazines were synthesized by the reaction of ketones with hydroxylamine hydrochloride in the presence of sodium acetate to give ketoximes 1(a-e). Chloramine-T was used as an effective reagent for the generation of ?-nitrosolefins from ketoximes 1(a-e) which subsequently underwent hetero Diels-Alder reaction with terminal acetylenes 4(a-d), to give 6H-1,2-Oxazine derivatives 5(a-t).

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  • ISSN(Print): 1916-9698
  • ISSN(Online): 1916-9701
  • Started: 2009
  • Frequency: semiannual

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