Spectroscopic Data of 3-O-beta-D-Glucopyranoside-betulinic Acid: An Anti-Cancer Agent


  •  Hamisu Abdu    
  •  Faujan Ahmad    
  •  M. Basri    
  •  Intan Ismail    
  •  M. B. Rahman    

Abstract

3-O-beta-D-Glucopyranoside-betulinic acid an anti-cancer agent compound, was prepared through enzymatic reaction of betulinic acid and glucose in organic solvent which gave 87.5% yield. Its spectroscopic data is now reported. Interestingly, 3-O-beta-D-glucopyranoside-betulinic acid also showed strong activity against cultured Human breast cancer (MCF-7), Human T-promyelocytic leukemia (HL-60) and Mouse embryonic fibroblast cancer (3T3) with IC50 values of 8.5, 8.4 and 2.75µg/ml respectively. However, it was found to have moderate activity against Human cervical carcinoma cancer (HeLa) cell line with IC50 value of 12.0µg/ml.



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  • ISSN(Print): 1916-9698
  • ISSN(Online): 1916-9701
  • Started: 2009
  • Frequency: semiannual

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