Synthesis of a New Spirolactone: 7,10-Dimethoxy-1-oxaspiro[4,5]deca-6,9-diene-2,8-dione
- Guy Plourde
- Mark D. Fairchild
- Gurkaran S. Sarohia
Abstract
The title compound was synthesized in 36 % yield by oxidative spiroannulation of the corresponding 2,4,5-trisubstituted phenol. Interestingly, this phenol was prepared in 57 % yield from another spirocompound, namely 7-methoxy-1-oxaspiro[4,5]deca-6,9-diene-2,8-dione. We have speculated that the formation of the phenol was due to a series of reactions involving a conjugate addition of methanol to the original spirolactone followed by aromatization and lactone hydrolysis.
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- DOI:10.5539/ijc.v4n1p2
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