Abstract

A series of novel azetidinones 5a-i have been synthesized by cyclocondensation of various Schiff bases of coumarin with chloro acetyl chloride in presence of triethyl amine. The reaction of 4-hydroxy coumarin with POCl₃ yielded 4-chloro coumarin 2 and 4-chloro-3, 4', 3', 4"-tercoumarin 2a. Compound 2 was reacted with p-phenylene diamine to yield 4-[(4-aminophenyl)amino]-2H-chromen-2-one. Various Schiff bases of coumarin were synthesized by condensation of 4-[(4-aminophenyl)amino]-2H- chromen-2-one with different aldehydes. The structures of the newly synthesized compound were confirmed by IR, ¹H NMR, ¹³C NMR and C, H, N analysis. The Schiff bases and azetidnie-2-one derivatives were evaluated for their anti bacterial and antifungal activity by broth dilution method.

This work is licensed under a Creative Commons Attribution 4.0 License.