Abstract

L-Tartaric acid which is chiral compound and commercially available, was converted into 1,3-dioxolane. In the synthetic sequence, 1,3-dioxolane was first formed via protection and partial hydrolysis of L-tartaric acid. Treatment with altered substituted aromatic amines, 1,3-dioxolane gave the desired amides i.e. ethyl 2,2-dimethyl-5-(phenylcarbamoyl)-1,3-dioxolane-4-carboxylate 3a,
2-(4-(ethoxycarbonyl)-2,2-dimethyl-1,3-dioxolane-5-carboxamido)benzoic acid 3b, ethyl
5-(4-iodophenylcarbamoyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 3c, ethyl
5-(2-chlorophenylcarbamoyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 3d and ethyl
5-(2,4-dichlorophenylcarbamoyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 3e. These chiral derivatives were purified through column chromatographic technique and characterized by different spectroscopic techniques i.e IR, ¹H NMR, ¹³C NMR and EIMS. The antimicrobial activities of these compounds were determined at different concentrations against different strains of bacteria and fungi.

This work is licensed under a Creative Commons Attribution 4.0 License.