Comparison of Quetiapine and Risperidone in Treatment of Acute Psychosis: A Double-Blind, Randomized-Controlled Study
- S. Mohammad Moosavi
- Mahshid Ahmadi
- Dianoosh Mojtahedi
- Jamshid Yazdani
- Mani B. Monajemi
Abstract
OBJECTIVE: The aim of this study was to evaluate the effectiveness of Quetiapine versus Risperidone in control of acute psychotic signs and symptoms in hospitalized patients during four weeks.
METHODS: In this double-blind, randomized controlled study, a total of 90 patients with a confirmed diagnosis acute psychosis and were hospitalized in Zare Hospital, Sari, Iran, and they were treated with Quetiapine (mean 500 mg/day) or Risperidone (mean 5.2 mg/day) , in a 4 week period. The positive and negative symptoms scale (PANSS) and Clinical Global Impression-Severity scale (CGI-s) were used to assess psychotic symptoms and severity of illness in first and the last day of the study.
RESULTS: No significant difference found between two groups in decreasing positive and negative sub-scores in the PANSS. Risperidone was superior to Quetiapine in decreasing the PANSS general psychopathology sub-scores and total score (p< 0.05). No significant difference found between two groups in decreasing CGI-s score.
- Full Text:
PDF
- DOI:10.5539/gjhs.v7n5p359
Journal Metrics
- h-index: 88 (The data was calculated based on Google Scholar Citations)
- i10-index: 464
- WJCI (2022): 0.897
- WJCI Impact Factor: 0.306
Index
- Academic Journals Database
- BASE (Bielefeld Academic Search Engine)
- CNKI Scholar
- Copyright Clearance Center
- DBH
- EBSCOhost
- Elektronische Zeitschriftenbibliothek (EZB)
- Excellence in Research for Australia (ERA)
- Genamics JournalSeek
- GHJournalSearch
- Google Scholar
- Harvard Library
- Index Copernicus
- Jisc Library Hub Discover
- JournalTOCs
- LIVIVO (ZB MED)
- MIAR
- Norwegian Centre for Research Data (NSD)
- PKP Open Archives Harvester
- Publons
- Qualis/CAPES
- ResearchGate
- ROAD
- SafetyLit
- Scilit
- SHERPA/RoMEO
- Standard Periodical Directory
- Stanford Libraries
- The Keepers Registry
- UCR Library
- UniCat
- UoB Library
- WJCI Report
- WorldCat
- Zeitschriften Daten Bank (ZDB)
Contact
- Erica GreyEditorial Assistant
- gjhs@ccsenet.org