Abstract

Background: Hair loss is a frequent and distressing manifestation among patients with hypothyroidism. In addition to thyroid hormone imbalance, deficiencies in vitamins and minerals may contribute to impaired hair follicle function.

Objective: This study aimed to assess serum vitamin and mineral profiles in patients with hypothyroidism-associated hair loss and to explore their relationship with thyroid hormone status.

Methods: the study was conducted on a total of 90 participants, including 65 patients diagnosed with hypothyroidism-associated hair loss, 25 control - and sex-matched apparently healthy control subjects, groups aged 30 and over. Serum levels of vitamin D3, vitamin B12, zinc, iron, ferritin, calcium, magnesium, thyroid-stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4) were measured using standard laboratory techniques. Venous blood samples were collected for analysis of hematological, hormonal and biochemical parameters. Comparative and correlation analyses were performed to evaluate differences between patients and controls and to assess associations between biochemical parameters and hair loss.

Results: Reduced serum levels of vitamin D3, vitamin B12 and calcium (P≤0.05), Iron (p < 0.01), ferritin (p < 0.01), Magnesium (p < 0.01) and zinc (p < 0.01) were commonly observed among patients with hair loss. Elevated TSH levels showed an inverse association with selected micronutrients, particularly iron stores and vitamin D3. No consistent association was found between calcium or magnesium levels and hair loss.

Conclusion: Micronutrient deficiencies are common among patients with hair loss associated with hypothyroidism. Periodic assessment of vitamin and mineral levels can support overall clinical management and help improve hair health.

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