Abstract

Background/Objective: Protein C (PC) is a vitamin K – dependent coagulation inhibitor produced in the liver. Acting together with its cofactor, protein S (PS), activated PC inhibits activated factors V and VIII thus downregulating thrombin generation which may predispose to inappropriate clot formation. This study aimed to ascertain the role of protein C deficiency in the development of ischaemic stroke in order to establish its relevance in stroke management in our environment.

Materials and Methods: Sixty-five ischaemic stroke patients and controls matched for age and sex were recruited in the study, blood samples were taken for haematological indices, prothrombin and activated partial thromboplastin times (PT and APTT) and protein C. Functional and qualitative assessments of protein C were done by chromogenic and immunoassay methods respectively. Data were analyzed with SPSS version 18.

Results: A total of 130 subjects comprising 65 stroke subjects and 65 controls were recruited in the study. Mean age of the stroke group was 60.4±12.3yrs and the control is 59.0±14.1yrs. The mean difference in PC Ag level, PC Ag(%) and functional activity between the groups were not statistically significant (p<0.05). Total WBC count in the stroke subjects was significantly higher than the controls (p=0.001). The platelet count was also higher and haemoglobin concentrations lower in stroke patients though not statistically significant. The prothrombin and activated partial thromboplastin times (APTT) in test and control groups are not significant.

Conclusion: This study showed that protein C may not play a significant role in the development of ischaemic stroke in our population.

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