Abstract

There were hospitalized patients diagnosed with Von Willebrand disorders (vWD) in this population medical base study. PubMed search bibliographies extracted applicable studies. Ten studies of 3296 patients diagnosed with vWD have been included in numerous research orders, ranging from 29.7% to 100%. The overall prevalence turned was 83.7% (95% CI 29.7-100%). The prevalence was 99.7 % (95 percent CI 99.3-100 %) higher in African and French research studies compared to 29.7% in America. This variation was pleasing to be as the results of different in these studies, which included the recruitment approach to population evaluation methods, blood loss, ethnic composition, and vWD mutation screening techniques criteria. The objective of this systematic review research was to evaluate the techniques of vWD mutation's screening. The mutation screening and its separate subtypes became a recommendation to use next - generation sequencing (NGS) and multiplex ligation - dependent probe amplification (MLPA) across the globe to check for analytical techniques that needed to be considered specifically for those of Caucasian origin and those with no obvious signs of pathological bleeding

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