The Side Effect of Haloperidol in Schizophrenic Patients: Analysis of Red Blood Cell Distribution Width (RDW) and Mean Platelet Volume (MPV) Values
- Andi Jayalangkara Tanra
- Hawaidah Hawaidah
- Yazzit Mahri
- Saidah Syamsuddin
- Andi Nilawati Usman
- Sonny Teddy Lisal
INTRODUCTION: Like the increase of pro-inflammatory cytokines and oxidative stress as schizophrenia pathophysiology, haloperidol also increases RDW and MPV values. Both of these values have been clinicians concern because they are a risk factor for the various type of vascular disease.
OBJECTIVE: This study aims to determine the side effect of haloperidol on RDW and MPV values in schizophrenic patients.
METHODS: This research method uses observational analytic design with a prospective cohort approach with pre and posts analysis conducted at the Regional Special Hospital of South Sulawesi Province during May - July 2018 in 30 schizophrenic subjects. The subjects were diagnosed as first episode schizophrenia based on ICD 10, blood samples were taken, for RDW and MPV values before and after haloperidol was given at the 4th and 8th weeks.
RESULTS: The results showed that the mean RDW value at the 4th week was higher in 15 mg/day haloperidol group (15.8) compared to 7.5 mg/day haloperidol group (15.3) with p<0.05. Mean RDW value taken at 8th week was higher in 15 mg/day haloperidol group (16.4) compared to 7.5 mg/day haloperidol group (15.6) with p<0.001. Mean MPV value taken at 8th week was higher in 15 mg/day haloperidol group (13.3) compared to 7.5 mg/day haloperidol group (11.6) with p<0.001.
CONCLUSION: This study showed an increase in the RDW value in schizophrenia subjects prior to the haloperidol administration. RDW and MPV values were higher after haloperidol treatment compares to before haloperidol treatment. The increase of RDW and MPV values tend to be influenced by haloperidol dosage and administration duration.
(The data was calculated based on Google Scholar Citations)
Google-based Impact Factor (2021): 0.50
ih-index (December 2021): 59
i10-index (December 2021): 290
RG Journal impact: 1.26
- Academic Journals Database
- BASE (Bielefeld Academic Search Engine)
- CNKI Scholar
- Copyright Clearance Center
- Elektronische Zeitschriftenbibliothek (EZB)
- Excellence in Research for Australia (ERA)
- Genamics JournalSeek
- Google Scholar
- Harvard Library
- Index Copernicus
- Jisc Library Hub Discover
- LIVIVO (ZB MED)
- Norwegian Centre for Research Data (NSD)
- PKP Open Archives Harvester
- Standard Periodical Directory
- Stanford Libraries
- The Keepers Registry
- UCR Library
- UoB Library
- Zeitschriften Daten Bank (ZDB)
- Erica GreyEditorial Assistant