Abstract

Oxaliplatin-based chemotherapy is the preferred first-line combination chemotherapy for metastatic colorectal cancer. In the last few years the generic oxaliplatin had been introduced, some personal observation that there may be difference in the spectrum of the side effects of this compound generic and the brand preparations. The use of generic drugs has become increasingly common in clinical practice. The generic drugs are chemical medicines have simple and well-defined structures that are manufactured after the patency of the medicine is over. We collected data from two group of patient who had colorectal cancer, 1^st group received the brand oxaliplatin based chemotherapy and 2^nd group received the generic oxaliplatin based chemotherapy. The hematological adverse effect was not significantly different between the 2 groups but the generic oxaliplatin is associated with higher non hematological side effect than the brand oxaliplatin, both peripheral sensory neuropathy and the hand- foot syndrome. Larger prospective randomised study needed to prove these data.

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