Abstract

Although several trials have been proposed for nasal polyposis (NP) treatment, but no standard guideline has been declared yet. We evaluated the effect of doxycycline on NP treatment. In a double- blind randomized clinical trial, 48 patients with bilateral nasal polyposis were assigned to receive doxycycline and placebo capsules for 8 weeks and were followed monthly for 4 months. Patients were assessed for polyp size, severity of symptoms and quality of life according to the endoscopic examination, VAS score, CT scanning and SNOT-22 respectively. polyp size reduced significantly after 8 weeks of treatment in the drug group. The quality of life score has raised significantly after 2 months of treatment with doxycycline. By giving –up the drug, severity of symptoms started to grow-up after 2 months. Although a course of doxycycline improved nasal symptoms, polyp size and CT findings, but further studies with more patients and longer follow-up course are required to establish the foundation to recommend this drug as an important treatment in NP.

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