Screening of Myxobacteria Strains Producing Bioactive Substances against Breast Cancer

Hongpeng Wang, Liping Zhang, Nan Shi


[Objective] To screen myxobacteria strains producing secondary metabolites with anti-cancer activity. [Method] Fermentation culture the stains of myxobacteria, extract secondary metabolites with methanol, and detect the antitumor activity of secondary metabolites from myxobacteria and its toxicity to normal cells with the modified MTT (3-[4,5-dimethythiazol-2-yl] -2,5-diphenyltetrazolium bromide) method. [Results] Inhibition rate of myxobacteria strain 93431 fermentation original solutions, 2 fold dilution and 10 fold dilution on MCF-7 cells was 53.32%, 49.35%, and 46.50%, respectively, and their inhibition rate on MRC cells was 2.95%, 5.90%, and 1.97%, respectively. [Conclusion] Secondary metabolites produced from strains 93431 could inhibit MCF-7 cells specifically while had little effects on MRC cells and the bioactive substances from its secondary metabolites could be natural target anti-cancer agents.

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