Synthesis of 6H-thiochromeno [3, 4-b] Quinoxaline Derivatives and their Antifungal Activities

Peng Wei, Jingjing Liu, Junjie Ma, Gengliang Yang


Objective: To design to synthesize 6H-thiochromeno [3, 4-b] quinoxaline derivatives and evaluate their antifungal activities.

Methods: The target compounds were prepared from substituted thiophenol by several steps, and separated by column chromatography.

Results: Four new unreported compounds were obtained. All compounds were confirmed by 1 H NMR and MS spectral analysis. Preliminary pharmacological test showed that two compounds both possessed potential antifungal activities.

Conclusion: The synthesized 6H-thiochromeno [3, 4-b] quinoxaline derivatives had certain antifungal activities in some tested fungal strains in vitro.

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Modern Applied Science   ISSN 1913-1844 (Print)   ISSN 1913-1852 (Online)

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