Synthesis of 3-substitutedmethylene-2H-thiopyrano[2,3-b] Pyridine-4(3H)-ones and Their Antifungal Activity In Vitro

Yajun Zheng, Zhengyue Ma, Xinghua Zhang, Ning Yang, Gengliang Yang


Six (Z)-3-substitutedmethylene-2H-thiopyrano[2,3-b]pyridin-4(3H)-ones were designed and synthesized. Their
structures were confirmed by MS and 1H-NMR and element analysis. Their antifungal activity was tested by micro
dilution broth susceptibility for eight kinds of fungi, and the results showed that the target compounds exhibited
activity against fungi tested to some extent. The compound 5a had the best antifungal effect among of the target

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International Journal of Chemistry   ISSN 1916-9698 (Print)   ISSN 1916-9701 (Online)

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