Antimicrobial Glycosides and Derivatives from Roots of Picralima nitida

Kouam Jacques, Laure B. K. Mabeku, Jules R. Kuiate, Alembert T. Tiabou, Zacharias T. Fomum


Phytochemical screening was performed on the roots of Picralima nitida, resulting in the isolation of three new coumestan glycosides, 3-hydroxy-9-methoxy-2-[2’(E)-3’-methyl-4’-O-?-D-galactopyranosylbutenyl]-8- isoprenylcoumestan (1), 3-hydroxy-9-methoxy-2-[2’(E)-3’-methyl-4’-O-?-D-glucopyranosylbutenyl]-8-[2”(E) -3”-methyl-4”-oxobutenyl]coumestan (2), and 3-hydroxy-9-methoxy-4-[2’(E)-3’-methyl-4’-O-?-D- glucopyranosylbutenyl]-8-[2”(E)-3”-methyl-4”-oxobutenyl]coumestan (3). Acid hydrolysis of 1, 2 and 3 afforded three new coumestan, 3-hydroxy-9-methoxy-2-[2’(E)-4’-hydroxy-3’-methylbutenyl]-8- isoprenylcoumestan (4), 3- hydroxy-9-methoxy-2-[2’(E)-4’-hydroxy-3’-methylbutenyl]-8-[2”(E)-3”-methyl-4”- oxobutenyl]coumestan (5), and 3-hydroxy-9-methoxy-4-[2’(E)-4’-hydroxy-3’-methylbutenyl]-8-[2”(E)-3”- methyl-4”-oxobutenyl]coumestan (6), respectively. Structures of these compounds were elucidated on the basis of spectroscopic data and chemical transformations. Compounds 1 - 6 showed antimicrobial activities against Escherichia coli, Staphylococcus aureus, and Proteus vulgaris.

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International Journal of Chemistry   ISSN 1916-9698 (Print)   ISSN 1916-9701 (Online)

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