International Journal of Chemistry
Synthesis of novel multifluorinated pyrazolone-5-one derivatives via conventional and non-conventional methods
Abstract
An efficient synthesis of 3-trifluoromethyl-1-(3,4-difluorophenyl)-1H-pyrazol-5(4H)-one (3) and their
Knoevenagel condensation reaction with 1,4-diphenyl -1H-pyrazole-3-carbaldehydes 4,
4-oxo-4H-chromene-3-carbaldehydes 6 and 2-chloroquinoline-3-carbaldehydes 8 have been described by using
conventional and non-conventional techniques. Comparison of conventional and non-conventional techniques
like Microwave , Ultrasonic assisted reactions showed that, the later procedure require shorter reaction time,
good yield and was applicable for larger set of substrates emphasizing the importance of eco-friendly conditions.
Knoevenagel condensation reaction with 1,4-diphenyl -1H-pyrazole-3-carbaldehydes 4,
4-oxo-4H-chromene-3-carbaldehydes 6 and 2-chloroquinoline-3-carbaldehydes 8 have been described by using
conventional and non-conventional techniques. Comparison of conventional and non-conventional techniques
like Microwave , Ultrasonic assisted reactions showed that, the later procedure require shorter reaction time,
good yield and was applicable for larger set of substrates emphasizing the importance of eco-friendly conditions.
This work is licensed under a Creative Commons Attribution 3.0 License.
International Journal of Chemistry ISSN 1916-9698 (Print) 1916-9701 (Online)
Copyright © Canadian Center of Science and Education
To make sure that you can receive messages from us, please add the 'ccsenet.org' domain to your e-mail 'safe list'. If you do not receive e-mail in your 'inbox', check your 'bulk mail' or 'junk mail' folders.