Lipase Catalysed Kinetic Resolution of Stiripentol

Elisabeth Egholm Jacobsen, Thorleif Anthonsen, Mohammed Farrag El-Behairy, Eirik Sundby, Mohamed Nabil Aboul-Enein, Mohamed Ibrahim Attia, Aida Abd El-Sattar El-Azzouny, Kamilia M. Amin, Mohamed Abdel-Rehim


Kinetic resolution of rac-Stiripentol, catalysed by lipase A from Candida antarctica by esterification with vinyl butanoate was performed with an E-value of 24. This allowed isolation of (3S)-Stiripentol with an ee of 86 % and the corresponding (3R)-butanoate with an ee of 87 %. Enzymatic hydrolysis of the ester product gave (3R)-Stiripentol with 94 % ee.

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International Journal of Chemistry   ISSN 1916-9698 (Print)   ISSN 1916-9701 (Online)

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