Diuretic Activity of Methanol Extracts of Rubus idaeus L.

Ying Zhang, Zhenya Zhang, Yingnan Yang, Yuepeng Wang, Xiaoyan Zu, Di Guan


The purpose of this article is to evaluate the diuretic potential of Rubus idaeus L. fruits. By measuring the urine
volume of experimental animals, we find that methanol extract of Rubus idaeus L. fruits significantly increased
the urine volume of experimental animals suggesting its diuretic effect. This is the first formal report on the
diuretic activity of Rubus idaeus L. fruits. Moreover, four fractions isolated from the methanol extract were
further studied and the results showed that ethyl acetate fraction (RIEA) has a direct relationship with the
diuretic activity of Rubus idaeus L. fruits. The urinary electrolyte patterns of experimental animals were also
analyzed, we find that Rubus idaeus L. fruits have an effect on the conservation of potassium, which is an
interesting property in a phyto-diuretic.

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DOI: https://doi.org/10.5539/ijb.v3n2p75

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