Effect of IGF-1 on Expression of GH Receptor, IGF-1, IGF-1 Receptor, KAP3.2 and KAP6-1 mRNA in the Skin of Sheep

Chengxian Zhang, Herong Liao, Yan Zhao


Thirty-six healthy and similar Chinese Merino sheep were selected and divided into six groups at random. The
treatment group was injected intradermally with 0.5 mL IGF-1 (10ng/mL). Treatment skin tissue of sheep were sampled
respectively for 0,3,6,9,12 and 50 days and the skin expression of growth hormone receptor (GHR), insulin-like growth
factor1 (IGF-1), insulin-like growth factor receptor (IGF- R), KAP3.2 and KAP6-1 mRNA were measured by RT-PCR.
The results indicated that IGF-1 could degrade GHR gene expression, have no effect of IGF-1 and IGF-1R gene
expression, and increase significantly KAP3.2 and KAP6-1 gene expression. Taken together these findings that the
improvement of KAP3.2 and KAP6-1 gene expression may correlates with other pathway beyond the insulin-like
growth factor axis.

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DOI: https://doi.org/10.5539/ijb.v1n1p65

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