Steroid hormone and antihormone induced changes in the pineal and adrenocortical karyomorphology and cell proliferation in mice ( Mus musculus )
- Rajasree Bandyopadhyay
- Moumita DasGupta
- Subrata Chakraborty
Abstract
In the present investigation steroid hormones, estradiol and testosterone and non-steroidal antihormones, tamoxifen and flutamide induced responsiveness in pineal and adrenal karyomorphology and cell proliferation activity was studied in post pubertal male mice (Mus musculus). Estradiol was injected at a dose of 5µg, testosterone 100 µg, tamoxifen 500 µg and flutamide 2 mg per 100 gm body weight administered intramuscularly in all cases for ten consecutive days. Control mice were similarly injected with oil vehicle 0.3 ml of peanut oil intramuscularly for same duration. The results indicated that except testosterone, all other treatments with estradiol, tamoxifen and flutamide caused significant hyperactivity of both the pineal and the adrenal gland associated with significantly increased cell proliferation activity. On the contrary testosterone administration was inhibitory to pineal - adrenal karyometric and mitotic incidence values. It was concluded that in male post pubertal mice both pineal and adrenal shows antagonistic response towards estradiol and testosterone administration. Although tamoxifen showed estrogen agonistic behaviour, flutamide on the reverse induced pineal and adrenal cytophysiological stimulation. Such stimulatory response was antagonistic to the inhibitory response shown by pineal and adrenal karyomorphology and cell proliferation following testosterone administration.
- Full Text: PDF
- DOI:10.5539/ijb.v2n2p25
Journal Metrics
h-index (December 2021 ): 37
i10-index (December 2021 ): 149
h5-index (December 2021 ): N/A
h5-median (December 2021 ): N/A
Index
- ACNP
- AGRICOLA
- BASE (Bielefeld Academic Search Engine)
- CAB Abstracts
- CiteFactor
- CNKI Scholar
- CrossRef
- DTU Library
- Elektronische Zeitschriftenbibliothek (EZB)
- Excellence in Research for Australia (ERA)
- Google Scholar
- Infotrieve
- LIVIVO (ZB MED)
- LOCKSS
- Max Planck Institutes
- MIAR
- PKP Open Archives Harvester
- Qualis/CAPES
- ResearchGate
- ROAD
- SafetyLit
- SHERPA/RoMEO
- Technische Informationsbibliothek (TIB)
- Universe Digital Library
- WorldCat
Contact
- Ryan JonesEditorial Assistant
- ijb@ccsenet.org