In vitro and In vivo Anti-Diabetic Activity of Extracts From Actinidia kolomikta

Xi Yuan, Xuansheng Hu, Yu Liu, Hongyi Sun, Zhenya Zhang, Delin Cheng

Abstract


Diabetes is a chronic disease, which occurs when the pancreas not produces enough insulin, or when the body cannot effectively utilise the insulin it produced. The anti-diabetic activities of both roots and leaves extracted by water and ethanol from Actinidia kolomikta (A. kolomikta) have been corroborated by this research by in vitro and in vivo tests. In the alpha-glucosidase inhibitory activity test, ethanol extract of roots showed the best inhibitory activity (74.2%, 6 mg/ml). Aqueous extracts from leaves prevented the increase in blood glucose level without causing a hypoglycemic state in the oral glucose tolerance test (120 min, 0.8 mg/g, 85.2 mg/dl) which performed in vivo and the maximum effect of the extract showed in 60 and 90 min after the administration of glucose. In the long term anti-diabetic test, the activities of regulation for the blood indicators demonstrated ethanol extracts of the roots from A. kolomikta has the effect to prevent and regulate the issue dysfunctions cause by complications of diabetes. The results reveal that roots and leaves of A. kolomikta, as forestry waste before, possess a high potential for the development of novel anti-diabetic drugs.


Full Text: PDF DOI: 10.5539/ijb.v6n3p1

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International Journal of Biology   ISSN 1916-9671(Print)   ISSN 1916-968X  (Online)

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