Antioxidant Activity and Immunomodulatory of Extracts From Roots of Actinidia kolomikta

Hongyi Sun, Shaofei Wang, Shuhong Li, Xi Yuan, Jian Ma, Zhenya Zhang

Abstract


Four extracts (AEA, AEB, AEC and AED), whose yields were 2.05%, 6.35%, 1.38% and 3.55%, respectively, were isolated and purified from the roots of Actinidia kolomikta in order to detect their antioxidant and immunomodulatory characteristics. In this study, AEC possessed the highest SOD-like activity (840.2 U/mg) and also showed stronger radical-scavenging activity (EC50, 152.2 ug/ml). In addition, for anti-proliferation, DLD-1 cells survival decreased to 30.8% at 50 ug/ml for 48 h by AEC. In this condition, the percentages of apoptosis cells were significantly increased from 0.85% to 17.30%. Moreover, AEB improved nitric oxide production and was shown to be more effective for immunomodulatory activity on macrophage survivals. The results indicate that all extracts from the roots of A. kolomikta exhibited strong antioxidant and immunomodulatory activities. These could provide a theoretical basis for A. kolomikta to be considered a nutritious functional material.


Full Text: PDF DOI: 10.5539/ijb.v5n3p1

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International Journal of Biology   ISSN 1916-9671(Print)   ISSN 1916-968X  (Online)

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