Homocysteine and Malondialdeyde (MDA) Levels Associated with the Occurrence of Cardiovascular Disease (CVD) in Chronic Renal Failure (CRF) in Malaysia

Shahin Arab, Huzwah Khazaai, Zarida Hambali, Zalinah Ahmad


Introduction: Atherosclerosis and following cardiovascular disease (CVD) are known as important reasons of
the increased morbidity and mortality observed in patients with chronic renal failure (CRF). The association of
serum malondialdehyde (MDA), homocysteine as well as other cardiovascular risk factors in relation to
existence and cause of CVD were investigated.
Methods: In these study 66 CRF patients without dialysis and 107 patients receiving dialysis were recruited and
further stratified into group with CVD and without CVD as case groups. Those without renal failure and CVD
were assigned as control group (n=33).
Results: The patients with CRF showed a significant increase in plasma levels of MDA, homocysteine and
C-reactive protein (CRP) compared to control. The positive association were observed between homocysteine,
creatinine and MDA (all p<0.01) and another positive association were between CRP and age, creatinine and
MDA (all p<0.05). Analysis of association risk factors showed that only age, CRP and lipid profile had
significant association with CVD events.
Conclusion: The results demonstrated elevation in plasma values of MDA, homocysteine and CRP in patients
with CRF, with or without CVD. However, these modifications may be lead to atherosclerosis and consequence
CVD event. These parameters may be important with respect to the high morbidity and mortality of CVD found
in patients with CRF.

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DOI: http://dx.doi.org/10.5539/gjhs.v3n1p119

Global Journal of Health Science   ISSN 1916-9736(Print)   ISSN 1916-9744(Online)

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