Uses of 2-Ethoxy-4(3H) quinazolinone in Synthesis of Quinazoline and Quinazolinone Derivatives of Antimicrobial Activity: The Solvent Effect

Maher A El-Hashash, Khalid M Darwish, Sameh A Rizk, Fakhry A El-Bassiouny

Abstract


Abstract: 2- Ethoxy-4(3H) quinazolinone 1 was synthesized and allowed to react with various halides, namely: alkyl, benzyl, allyl, acyl, haloacetyl, crotonyl, benzoyl, 2-furoyland1-naphthalenesulphonyl halides affording quinazoline and quinazolinone derivatives. The reactions of compound 1 with phosphorus oxychloride, phosphorus pentasulfide, ethyl chloroformate, ethyl chloroacetate, ?-bromoglucose tetraacetate, p-acylaminobenzenesulfonyl chloride, acrylonitrile, chalcone and chalcone oxide were also investigated. Dependingon the reaction condition and reactant halide, thetype of substituent (alkyl, acyl, aroyl, etc.) that will reside on either of the expected positions (3or4)onthequinazoline moiety cancontrolthe reaction pathwayfor synthesis of the promising products. The significant role of solvent responsible for determining both the reaction pathway and type of products synthesized was also discussed. Some derivatives were chosen for biological screening test against Gram (-ive) and Gram (+ive) bacteria and two strains of fungi.


Full Text: PDF DOI: 10.5539/gjhs.v4n1p162

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Global Journal of Health Science   ISSN 1916-9736(Print)   ISSN 1916-9744(Online)

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