Design, Synthesis and Antifungal Activity of 3-substituedmethylenethiochroman-4-one Derivatives

Xinghua Zhang, Zhengyue Ma, Gengliang Yang, Yajun Zheng


Four new 3-substituedmethylenethiochroman-4-one derivatives were prepared from (z)-3-(chlorome- thylene)thiochroman-4-one. They were characterized by analytical and spectral methods. In vitro antifungal activities of these synthesized compounds were evaluated against ten species of fungi, and the results showed that (e)-3-chloromethylene compound exhibited a similar good activity against fungi to (z)-3-chloromethylene compound. (Z)-3-substituedaminomethylene compound also exhibited antifungi activity to some extent.

Full Text:



Copyright (c)

Modern Applied Science   ISSN 1913-1844 (Print)   ISSN 1913-1852 (Online)  Email:

Copyright © Canadian Center of Science and Education

To make sure that you can receive messages from us, please add the '' domain to your e-mail 'safe list'. If you do not receive e-mail in your 'inbox', check your 'bulk mail' or 'junk mail' folders.