Effects of Tween-80 on the Dissolution Properties of Daidzein Solid Dispersion in Vitro

Lijuan Hu, Na Zhang, Gengliang Yang, Jingyu Zhang

Abstract


Objective Solid dispersions of daidzein (DZ) were prepared using tween-80 as the surfactant to improve its
dissolution and solubility. Methods Using tween-80 as the surfactant and polyethylene glycol (PEG)-10000 as the
carrier, solid dispersions of DZ were prepared by solvent method. Infrared spectroscopy (IR) and X-ray diffraction
spectroscopy were applied to determine the status of DZ in carriers. Results When appropriate amount of Tween-80
was added into the solid dispersion, the dissolution of DZ could be improved obviously. The data of IR showed the
absence of well-defined drug-polymer interactions. The data of X-ray diffraction showed that the drug might exist in
the form of amorphism or molecule in solid dispersions. Conclusion Appropriate amount of Tween-80 could
increase the dissolution rate of DZ.

Full Text: PDF DOI: 10.5539/ijc.v3n1p68

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International Journal of Chemistry   ISSN 1916-9698 (Print)   1916-9701 (Online)

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