Synthesis and Antibacterial Activity of Novel Organoselenium Compounds

Radhakrishna P M, Sharadamma K C, Vagdevi H M, Abhilekha P M, Rubeena Mubeen S, Nischal K

Abstract


Organoselenium compounds are known to possess antioxidant, anticancer and antibacterial activities. In the present study, 3-[(phenylcarbonyl)selenyl]propanoic acid was synthesized and different ester derivatives of 3-[(phenylcarbonyl)selenyl]propanoic acid and benzoylselenoglycolic acid were synthesized and characterized using IR, NMR and Mass spectroscopy. Minimum Inhibitory Concentration (MIC) of the newly synthesized compounds was determined against gram positive and gram negative bacteria. Some of the compounds showed moderate to significant activity against Staphylococcus aureus, Salmonella typhimurium, Escherichia coli and Bacillus cereus.


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International Journal of Chemistry   ISSN 1916-9698 (Print)   1916-9701 (Online)

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