Synthesis and Antimicrobial Studies on New Substituted 1,3,4-Oxadiazole Derivatives Bearing 6-Bromonaphthalene Moiety


  •  Anil Mayekar    
  •  Hemmige Yathirajan    
  •  B. Narayana    
  •  B. K. Sarojini    
  •  N. Kumari    

Abstract

A series of new 1,3,4-oxadiazole derivatives having 6-bromonaphthalene moiety are synthesized.
2-[(6-bromo-2-naphthyl)oxy]acetohydrazide was treated with various substituted aromatic acids in presence of POCl3 to
give 2-{[(6-bromo-2-naphthyl)oxy]methyl}-5-aryl-1,3,4-oxadiazole. Also the hydrazide on treating with CS2/KOH
gave 5-{[(6-bromo-2-naphthyl)oxy]methyl}-1,3,4-oxadiazole-2(3H)-thione, which was subjected to Mannich reaction
to get a series of Mannich bases and with alkyl/aryl halide to give
2-{[(6-bromo-2-naphthyl)oxy]methyl}-5-[(alkyl/aryl)thio]-1,3,4-oxadiazole. The newly synthesized compounds were
characterized by analytical and spectral data. Antimicrobial activities of these compounds were carried out and some of
them have exhibited good activity.



This work is licensed under a Creative Commons Attribution 4.0 License.
  • ISSN(Print): 1916-9698
  • ISSN(Online): 1916-9701
  • Started: 2009
  • Frequency: semiannual

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