Spectroscopic Data of 3-O-beta-D-Glucopyranoside-betulinic Acid: An Anti-Cancer Agent

Hamisu Abdu, Faujan B. H. Ahmad, M. Basri, Intan Safinar Ismail, M. B. Abdul Rahman

Abstract


3-O-beta-D-Glucopyranoside-betulinic acid an anti-cancer agent compound, was prepared through enzymatic reaction of betulinic acid and glucose in organic solvent which gave 87.5% yield. Its spectroscopic data is now reported. Interestingly, 3-O-beta-D-glucopyranoside-betulinic acid also showed strong activity against cultured Human breast cancer (MCF-7), Human T-promyelocytic leukemia (HL-60) and Mouse embryonic fibroblast cancer (3T3) with IC50 values of 8.5, 8.4 and 2.75µg/ml respectively. However, it was found to have moderate activity against Human cervical carcinoma cancer (HeLa) cell line with IC50 value of 12.0µg/ml.


Full Text: PDF DOI: 10.5539/ijc.v4n5p28

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International Journal of Chemistry   ISSN 1916-9698 (Print)   ISSN 1916-9701 (Online)

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