A Simple and Efficient Green Method for the Deprotection of N-Boc in Various Structurally Diverse Amines under Water-mediated Catalyst-free Conditions

Cheraiet Zinelaabidine, Ouarna Souad, Jamel Zoubir, Berredjem Malika, Aouf Nour-Eddine


A simple, efficient and eco-friendly protocol has been developed for the deprotection of N-Boc on structurally diverse amines. Selective removal of N-Boc groups was achieved with excellent yields using water around reflux temperatures. In the absence of any additional reagents, this method represents a reasonable alternative to previously reported deprotection procedures.


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DOI: http://dx.doi.org/10.5539/ijc.v4n3p73

International Journal of Chemistry   ISSN 1916-9698 (Print)   ISSN 1916-9701 (Online)

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