Synthesis and Biological Activity Evaluation of Some New Heterocyclic Spirocompounds with Imidazolinone and Pyrazoline Moieties

Omar Abdelhay Miqdad, Nada M. Abunada, Hamdi M. Hassaneen, Ahmed S. M. Abu Samaha

Abstract


The synthesis of antimicrobial activity spirocompounds was achieved via the reaction of hydrazonoyl halides 1 with exocyclic 4-arylidene-2-methylimidazolin-5-one 3 in benzene in the presence of triethylamine. Correct elemental analyses and spectral data (IR, 1H NMR, 13C NMR and MS) confirm the structure of the synthesized spirocompounds. All the synthesized compounds were evaluated in vitro for their antimicrobial activity against five gram-positive and two gram-negative bacteria using well diffusion method in Mueller-Hinton agar. Most of them exhibited significant antibacterial activity compared with selected standard drugs.


Full Text: PDF DOI: 10.5539/ijc.v3n4p20

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International Journal of Chemistry   ISSN 1916-9698 (Print)   1916-9701 (Online)

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