DNA Damage in Workers Occupationally Exposed to Lead, Using Comet Assay

Pappuswamy Manikantan, V. Balachandar, K. Sasikala


Lead is one of the most clinically important heavy metals, because it induces a broad range of physiological,
biochemical, and genetical dysfunctions. Occupational exposure to lead leads to increased frequency of genetic system
in human beings. In the present study the DNA damage among the workers occupationally exposed to lead was
analyzed using peripheral blood lymphocyte by comet assay. The result of this study shows increased levels of DNA
damage among experimental subjects. The habit of cigarette smoking among the workers has a synergistic effect on
inducing DNA damage.

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DOI: https://doi.org/10.5539/ijb.v2n1p103

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