The Role of Transcription Factors in Cytokine-Mediated Apoptosis of Lymphocytes

Olga Evgenevna Saveleva, Larisa Sergeevna Litvinova, Evgeniya Sergeevna Anishchenko, Viacheslav Viktorovish Novitsky, Nataliya Vladimirovna Riazantseva

Abstract


The role of transcription factors in the implementation of IL-2 and IL-4 proapoptotic effects investigated in the in vitro experiment. It is shown that recombinant IL-2 at a dose of 0.10 ng/ml and IL-4 at a dose of 0.15 ng/ml have apoptotic effects on lymphocytes. At the apoptosis induction by rIL-2 and rIL-4 the transcription factors NF-kB, p53, pRb and inhibitor of cyclin-dependent kinases p21WAF1/CIP1 are activated.


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DOI: http://dx.doi.org/10.5539/ijb.v4n1p129

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