Association of Tumor Growth Factor-β and Interferon-γ Serum Levels With Insulin Resistance in Normal Pregnancy
- Abdolreza Sotoodeh Jahromi
- Mohammad Sadegh Sanie
- Alireza Yusefi
- Hassan Zabetian
- Parvin Zareian
- Hossein Hakimelahi
- Abdolhossien Madani
- Mohammad Hojjat-Farsangi
Abstract
Pregnancy is related to change in glucose metabolism and insulin production. The aim of our study was to determine the association of serum IFN-γ and TGF- β levels with insulin resistance during normal pregnancy. This cross sectional study was carried out on 97 healthy pregnant (in different trimesters) and 28 healthy non-pregnant women. Serum TGF-β and IFN- γ level were measured by ELISA method. Pregnant women had high level TGF-β and low level IFN-γ as compared non-pregnant women. Maternal serum TGF-β concentration significantly increased in third trimester as compared first and second trimester of pregnancy. Maternal serum IFN-γ concentration significantly decreased in third trimester as compared first and second trimester of pregnancy. Pregnant women exhibited higher score of HOMA IR as compared non-pregnant women. There were association between gestational age with body mass index (r=0.28, P=0.005), TGF-β (r=0.45, P<0.001) and IFN-γ (r=-0.50, P<0.001). There was significant association between Insulin resistance and TGF-β (r=0.17, p=0.05). Our findings suggest that changes in maternal cytokine level in healthy pregnant women were anti-inflammatory. Furthermore, Tumor Growth Factor-β appears has a role in induction insulin resistance in healthy pregnant women. However, further studies needed to evaluate role of different cytokines on insulin resistance in normal pregnancy.- Full Text: PDF
- DOI:10.5539/gjhs.v8n6p25
This work is licensed under a Creative Commons Attribution 4.0 License.
Journal Metrics
(The data was calculated based on Google Scholar Citations)
Google-based Impact Factor (2021): 0.50
ih-index (December 2021): 59
i10-index (December 2021): 290
RG Journal impact: 1.26
Index
- Academic Journals Database
- BASE (Bielefeld Academic Search Engine)
- CNKI Scholar
- Copyright Clearance Center
- DBH
- EBSCOhost
- Elektronische Zeitschriftenbibliothek (EZB)
- Excellence in Research for Australia (ERA)
- Genamics JournalSeek
- GHJournalSearch
- Google Scholar
- Harvard Library
- Index Copernicus
- Jisc Library Hub Discover
- JournalTOCs
- LIVIVO (ZB MED)
- MIAR
- Norwegian Centre for Research Data (NSD)
- PKP Open Archives Harvester
- Publons
- Qualis/CAPES
- ResearchGate
- ROAD
- SafetyLit
- Scilit
- SHERPA/RoMEO
- Standard Periodical Directory
- Stanford Libraries
- The Keepers Registry
- UCR Library
- UniCat
- UoB Library
- WorldCat
- Zeitschriften Daten Bank (ZDB)
Contact
- Erica GreyEditorial Assistant
- gjhs@ccsenet.org